Alzheimer's Causes & Risk Factors

Your Alzheimer’s Questions Answered: Q&A with Rudy Tanzi

Posted: Apr. 17, 2014

We collected your questions about Alzheimer's from our fall symposium and social media and presented them to Dr. Rudy Tanzi, chairman of our Research Consortium. Watch the videos below!

Circadian Clock Proteins a Potential Therapeutic Target for Alzheimer’s

Posted: Dec. 19, 2013

Brain aging is associated with lower production of circadian clock proteins, which synchronize biological processes to light and dark cycles. In Alzheimer’s and other neurodegenerative diseases, circadian dysfunction is commonly observed.

Alzheimer's Proteins Found In Cerebrospinal Fluid of Older Patients Post Surgery

Posted: Jul. 1, 2013

BOSTON – New research examining levels of the hallmark proteins linked to Alzheimer's disease found in patients suffering from post-operative cognitive changes (POCC) may lead to safer surgery care and better post-operative outcomes for senior adults.

Exposure to Air Pollution May Increase Risk of Alzheimer’s Disease

Posted: Apr. 14, 2013

The study, led by Cure Alzheimer’s Research Consortium member Sam Gandy, M.D., Ph.D., of the Icahn School of Medicine at Mount Sinai, examined how elements in air pollution such as nickel nanoparticles affect the levels of certain peptides in the brain that are found to be at heightened levels in patients suffering from Alzheimer’s Disease.

“We don’t yet completely understand why the peptides accumulate, but we do know the genes responding to the peptides play an important role in developing Alzheimer’s,” said Gandy.

Traumatic Brain Injury Linked to Alzheimer's and Other Neurodegenerative Diseases

Posted: Apr. 11, 2013

Traumatic Brain Injury (TBI) can lead to neurodegenerative syndromes that include Alzheimer's Disease (AD) and Chronic Traumatic Encephalopathy (CTE).

The April issue of Nature Reviews Neurology is devoted to Traumatic Brain Injury (TBI) and Chronic Traumatic Encephalopathy (CTE). Cure Alzheimer’s Fund research consortium member, Sam Gandy, M.D., Ph.D., of the Icahn School of Medicine at Mount Sinai is senior author of the lead review and overview.

Featured Researcher: Giuseppina Tesco, M.D., Ph.D.

Posted: Jan. 23, 2013

Meet Dr. Giuseppina Tesco, Cure Alzheimer’s Funded researcher, and assistant professor of neuroscience, Alzheimer’s Disease Research Laboratory, Department of Neuroscience, Tufts University School of Medicine.

Early Days

Origins of Alzheimer's Increasingly Clear

Posted: Nov. 11, 2012

Consensus among Alzheimer’s researchers about the origins of the disease is growing. Most, including members of Cure Alzheimer’s Fund Research Consortium, agree that a combination of factors, beginning with the excessive build-up of the peptide Abeta42  triggering  the development of tau tangles, nerve cell death, and inflammation are all required for Alzheimer’s pathology.

Alzheimer's and Diabetes: Finding the Common Origin

Posted: Mar. 6, 2012

Alzheimer’s disease and Type II diabetes long have been observed to have a clinical connection, with patients with diabetes more than twice as likely as those without the disease to develop Alzheimer’s. But the precise nature of this connection has been a mystery until recently. Over the last few years, research projects funded by Cure Alzheimer’s Fund and others have helped bring us much closer to an understanding of the molecular connection—and, potentially, to effective treatments for both diseases.