Paul Greengard, Ph.D.

Headshot photo

Nobel Prize in Physiology and Medicine, 2000
Head of the Laboratory of Molecular and Cellular Neuroscience
Vincent Astor Professor, The Rockefeller University.

Dr. Greengard has served on the editorial boards of more than 25 journals, and advises a wide range of organizations, including the National Institutes of Health National Advisory Council on Aging, (2004–).

From the website of the Rockefeller University, Dr. Greengard writes of his current work:
"The goals of the research group are to understand more fully the molecular basis of communication between neurons in the adult mammalian brain and to elucidate the molecular defects responsible for various neurological and psychiatric disorders.

"Specifically with regard to Alzheimer’s disease, we have demonstrated that the relative amounts of APP that are converted to the nontoxic soluble form of APP (APPs) and the toxic beta-amyloid are controlled by protein phosphorylation and dephosphorylation mechanisms. Thus, activators of various protein kinases, as well as inhibitors of various protein phosphatases, reduce the amount of beta-amyloid formed by nerve cells. We are now determining the components of the signal transduction cascade that are responsible for the regulation of APP breakdown, and the formation of beta-amyloid, with the aim of developing new targets for the treatment of Alzheimer's disease."

 

Funded Research

Project Description Researchers Funding
Selective Cell Vulnerability in Alzheimer's Disease

The goal of this project is to identify cells that are both most vulnerable and most resistant to Alzheimer’s disease in order to develop drugs that will protect the most vulnerable.

2011
$100,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Kurup P, Zhang Y, Xu J, Venkitaramani DV, Haroutunian V, Greengard P, Nairn AC, Lombroso PJ, Aβ-Mediated NMDA Receptor Endocytosis in Alzheimer's Disease Involves Ubiquitination of the Tyrosine Phosphatase STEP, The Journal of Neuroscience, 30(17), Apr 28 2010, 5948-5957
Zhang Y-w, Liu Shijie, Zhang X, Li W-B, Chen Y, Huang X, Sun L, Luo W, Netzer WJ, Threadgill R, Wiegand G, Wang R, Cohen S, Greengard P, Liao F-F, Li L, Xu H, A Functional Mouse Retroposed Gene Rps23r1 Reduces Alzheimer's β-Amyloid Levels and Tau Phosphorylation, Neuron, 64(3), Nov 12, 2009, 328-40
Lagace D, Benavides D, Kansy J, Mapelli M, Greengard P, Bibb J, Eisch A, Cdk5 is essential for adult hippocampal neurogenesis, Proceedings of the National Academy of Science, Vol. 105 No. 47, October 9, 2008, 18567-18571