Cure Alzheimer’s Fund Oligomer Collaborative
Monday, 31 August 2009 12:21
A collaboration of members of the Research Consortium, a member of the Cure Alzheimer’s Fund Science Advisory Board, and non-Cure Alzheimer’s Fund affiliated researchers hypothesize that an abnormal increase in levels of synaptic Abeta and particularly, Abeta oligomers may lead to synaptic dysfunction, cognitive decline, and eventually dementia. This highly innovative collaborative project will address how Abeta oligomers are formed and which types detrimentally impact synaptic dysfunction and neuronal survival in the brain.
As a result of promising results from the first year of work, the original members of the collaborative were re-funded for a second year in August, 2007. Two more researchers, Sam Gandy of Mount Sinai Medical School and Tae-Wan Kim of Columbia University, joined the Oligomer Collaborative and were also funded in August.
The project has grown in the third year to include a broader view of the Abeta synaptic feedback loop.
Dr. Charles Glabe,
University of California at Irvine
The Role of Oligomeric Abeta in Alzheimer’s Disease
Dates Funded:
June, 2006: $100,000
August, 2007: $100,000
Dr. Virginia M.-Y. Lee,
University of Pennsylvania
Abeta Oligomers in Mouse Models of Alzheimer’s Disease
Dates Funded:
June, 2006: $100,000
August, 2007:
$100,000
August, 2008: $100,000
Drs. Rudolph Tanzi and Robert Moir,
Massachusetts General Hospital
Identification of agents that inhibit the generation and neurotoxicity of cross-linked Beta amyloid protein species (CAPS)
Dates Funded:
June, 2006: $100,000
August 2007: $100,000
Dr. Sangram Sisodia,
University of Chicago
Molecular Analysis of Abeta*56 Structure and Function
Molecular Mechanisms Underlying Hippocampal Neurogenesis by Familial Alzheimer’s disease-linked Presenilin-1 Variants
Dates Funded:
June, 2006: $100,000
August 2007: $100,000
September, 2008: $100,000
Dr. Paul Greengard,
The Rockefeller University
The Role of Oligomeric Abeta in Synaptic Transmission and Plasticity
Dates Funded:
June, 2006: $100,000
August 2007: $100,000
Dr. David Holtzman,
Washington University
Role of Synaptic Activity and Neurotransmitter Modulation in the Dynamic Regulation of Interstitial Fluid Abeta and Oligomer Formation
Defining effects of physiological synaptic activity on Abeta levels: Implications for Alzheimer’s disease
Dates Funded:
June, 2006: $100,000
August 2007: $100,000
September, 2008: $100,000
Dr. Sam Gandy,
Mount Sinai Medical School
Elucidation of the biology of Abeta oligomers by performing quantitative characterizations of mice of four distinct genotypes for use by members of the Cure Collaborative.
Dates Funded:
August 2007: $100,000
Dr. Tae-Wan Kim
Columbia University Medical Center
Role for phosphoinositides in Abeta oligomer-associated synaptic dysfunction.
Dates Funded:
August 2007: $100,000
Dr. William Van Nostrand
Stony Brook University
Modulation of Abeta Assembly and Cytotoxicity by a Fragment of Myelin Basic Protein.
Dates Funded:
September, 2008: $100,000
Dr. Roberto Malinow
University of California at San Diego
Understanding the Cell Biology Underlying the Effects of Abeta on Synapses
Dates Funded:
September, 2008: $100,000
Drs. Robert Moir and Rudolph Tanzi
Massachusetts General Hospital
The Role of Abeta Oligomerization in the Abeta-mediated Disruption of Lipid Bylayers.
Dates Funded:
June, 2008: $200,000
Dr. Stephen Strettmatter
Yale University
Specificity and Mechanism of Abeta-Oligomer Action through Prion Protein
Dates Funded:
March, 2009: $100,000
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